Irinotecan is converted by an enzyme into its active metabolite SN-38, which is in turn inactivated by the enzyme UGT1A1 by glucuronidation. People with variants of the UGT1A1 called TA7, also known as the "*28 variant", express fewer UGT1A1 enzymes in their liver and often have Gilbert's syndrome. During chemotherapy, they effectively receive a larger than expected dose because their bodies are not able to clear irinote… WebIrinotecan (liposomal) is the generic name for the trade name drug Onivyde. In some cases, health care professionals may use the trade name Onivyde when referring to the generic …
Comparison of the second-line treatments for patients with small …
WebJul 1, 2005 · On the contrary, taxanes, vinca alkaloids, irinotecan, and anthracyclines may result in unacceptable toxicity (see Table 2 for recommended dose adjustments). There are very few data regarding combination regimens. Likewise, there are few data regarding the antitumor efficacy of chemotherapy in this setting. WebJun 23, 2024 · Thuss-Patience PC, Kretzschmar A, Bichev D, et al. Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer— a randomised phase III study of ... field navigation gps
Second-Line Therapy in Colorectal Cancer - Cancer Network
WebThere are few studies on the impact of UGT1A1*28 gene polymorphism on the efficacy of CPT-11. 28 The clinical studies demonstrated that irinotecan-based chemotherapy can … WebMay 9, 2024 · This topic review will provide an overview of the incidence and specific patterns of lung toxicity seen with cytotoxic chemotherapy agents. Separate monographs are available for many of the drugs that are most commonly associated with pulmonary toxicity. ... Fukuda H, et al. Dose-escalation study of weekly irinotecan and daily … WebMay 21, 2024 · Chemotherapy medications with the highest risk of causing hair loss (or at least significant hair thinning) in many people include: 4. Cytoxan or Neosar (cyclophosphamide) Ifex (ifosfamide) Adriamycin or Doxil (doxorubicin) Vepesid or Toposar (etoposide) Camptosar (irinotecan) greystone cleaners birmingham al