Circhif1a
WebApr 15, 2024 · CircHIF1A promoted TNBC progression both in vitro and in vivo A (left) Cluster heat map showed the differentially expressed genes in MDA-MB-231 cells with circHIF1A overexpression and control cells. WebJan 4, 2024 · Zhan et al. have found that circHIF1A from CAF-derived exosomes can be taken up by breast cancer cells and thus plays an important role in the regulation of cancer stem cell properties by sponging miR-580-5p and therefore changing CD44 expression. In addition, exosomal circsl7a6 secreted by CAFs is reported to promote the initiation of CRC.
Circhif1a
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WebJul 15, 2024 · The RNA-binding protein FUS regulates the biogenesis of circHIF1A by interacting with flanking introns, and significantly promotes TNBC growth and metastasis . 4. Cis-Regulatory Elements. In addition to trans-acting factors that regulate circRNA biogenesis, many cis-regulatory elements can also influence the cyclization of RNA. In … WebJan 11, 2024 · In support of circHIF1A as a biomarker and target molecule for breast cancer therapy, Zhan and colleagues identified this molecule in a screening of circRNA present in exosomes from hypoxic CAFs in breast cancer . circHIF1A from hypoxic CAFs-derived exosomes proved to be an important player in conferring stem cell properties to breast …
WebTong Chen et al. (2024) revealed that circHIF1A, which was upregulated in the plasma of BC patients, could be selectively loaded into exosomes secreted by BC cells. CircHIF1A promoted TNBC growth and metastasis by regulating NFIB expression and subcellular location and was involved in the circHIF1A/NFIB/FUS positive feedback loop. WebK The relative RNA levels of circHIF1A and linear HIF1A were analyzed by qRT-PCR assay after treatment with Actinomycin D in MDA-MB-231 cells. L The relative RNA levels of circHIF1A, linear HIF1A ...
WebLoop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. WebApr 3, 2024 · This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, …
WebApr 19, 2024 · A recent study revealed that circHIF1A (hsa_circ_0004623) promoted cancer cell proliferation and metastasis in triple-negative breast cancer (TNBC). Mechanistically, circHIF1A regulates the expression and translocation of NFIB through post-transcriptional and post-translational modifications, resulting in activation of the AKT/STAT3 signaling ...
WebAug 20, 2024 · The RNA-binding protein FUS regulates the biogenesis of circHIF1A by interacting with flanking introns, and significantly promotes TNBC growth and metastasis . Go to: 4. Cis-Regulatory Elements. In addition to trans-acting factors that regulate circRNA biogenesis, many cis-regulatory elements can also influence the cyclization of RNA. In ... ina garten beef stew crock potWebJun 14, 2024 · [Cell Death Discovery] Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated … in 1800 where did most americans liveWebMoreover, circHIF1A could be packaged into exosomes and was upregulated in the plasma of breast cancer patients. Our findings indicated that circHIF1A played a critical role in the growth and metastasis of TNBC via a positive feedback loop and that circHIF1A could be a promising biomarker for breast cancer diagnosis and a potential therapeutic ... in 1803 the louisiana territory brainlyWebThe breast cancer cells were used to establish the models in BALB/C nude mice and hypoxia exosomes with circHIF1A shRNA or the controls were injected into the nude … in 1796 what did the jay treaty accomplishWebChen, T., Wang, X., Li, C., Zhang, H., Liu, Y., Han, D., … Yang, Q. (2024). CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by ... ina garten beef stew with short ribsWebJun 12, 2024 · CircHIF1A may act as a target molecule of breast cancer therapy. Hypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast … ina garten beef stroganoff easyFirst, we constructed a circHIF1A overexpression plasmid and designed two small interfering RNAs (siRNAs) targeting the splicing junction of circHIF1A. CircHIF1A overexpression and knockdown efficiencies in TNBC were validated by qRT-PCR (Supplementary Fig. 2A). The expression levels of linear HIF1A … See more Fused in sarcoma (FUS) belongs to the FET family of ubiquitously expressed RNA-binding proteins involved in multiple stages of RNA processing [30, 31]. Recently, FUS was … See more Interestingly, we found that ectopic expression of NFIB could increase circHIF1A expression, while NFIB knockdown led to … See more Because the potential roles of FUS in TNBC progression are largely unknown, we conducted functional experiments with FUS overexpression … See more in 1803 the louisiana territory quizlet