Ctgf target
WebApr 11, 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver fibrosis. Although accumulating evidence has shown that HBV directly stimulates HSC activation, … WebHere, we describe the molecular and biological characteristics of CTGF, its regulation and various functions in the spectrum of development and regeneration to fibrosis. We further …
Ctgf target
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WebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor … WebIncreasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. The interplay of tumor cells and the tumor microenvironment significantly affects the efficacy of therapeutic agents. The functional importance of CTGF provides an opportunity to disrupt ECM-mediated protection and to target tumors directly.
WebApr 17, 2024 · Focus on the target genes that affect tumor invasion and metastasis, providing the possibility for the selection of clinical drug treatment targets, to provide some help for a more in-depth study of tumor invasion and migration mechanism and the development of clinical drugs. ... CTGF. Connective tissue growth factor (CTGF) is a … WebMar 23, 2024 · As shown in Figure S3C, overexpression of NFATC2 significantly upregulated the expression levels of the target genes of Hippo/YAP signaling pathway (CTGF and Gli2) 18–20 in both HCT-116 and HT-29 cells. Conversely, reduced mRNA expression levels of CTGF and Gli2 were observed in NFATC2-knockdown HCT-116 …
WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the … WebSep 6, 2024 · Our previous studies showed that Cx43 was a downstream target protein of CTGF in chondrocytes that regulated cell-to-cell communication [27, 31]. Simultaneously, cementocytes specifically express Cx43 as a gap junction carrier to facilitate intercellular communication . Therefore, we speculated that Cx43 regulated by CTGF was involved in …
Several clinical trials are now ongoing that investigate the therapeutic value of targeting CTGF in fibrosis, diabetic nephropathy, and pancreatic cancer. CTGF (CCN2) has recently been implicated in mood disorders, notably in the postpartum period; these effects may be mediated by its effects on … See more CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). … See more Members of the CCN protein family, including CTGF, are structurally characterized by having four conserved, cysteine-rich domains. These domains are, from N- to C-termini, the insulin-like growth factor binding protein (IGFBP) domain, the von … See more • Ctgf/hcs24 CAESAR • CYR61 (CCN1) See more • Human CTGF genome location and CTGF gene details page in the UCSC Genome Browser. See more Knockout mice with the Ctgf gene disrupted die at birth due to respiratory stress as a result of severe chondrodysplasia. … See more CTGF is associated with wound healing and virtually all fibrotic pathology. It is thought that CTGF can cooperate with TGF-β to induce sustained fibrosis and to exacerbate extracellular matrix production in association other fibrosis-inducing conditions. … See more
WebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to … open the book to page twoWebFeb 13, 2024 · The downstream target genes of YAP that are of primary interest in this study are Connective Tissue Growth Factor (CTGF) and Cysteine-rich angiogenic protein … ipc holdq threshold upperWebIn this review, we comprehensively discuss the expression of CTGF and its regulation, oncogenic role, clinical relevance, targeting strategies, and therapeutic agents. Herein, … open the box game onlineWebApr 12, 2024 · Gene expression analysis showed that USP1 depletion further decreased the expression of CTGF and CYR61, which are the most classical Hippo target genes, in HLF and Hep3B cells (Fig. 2C, G), while ... ipc honduras 2020WebTANF. Temporary Assistance for Needy Families (TANF), commonly known as welfare, is the monthly cash assistance program for low-income families with children under age 18. … ipc holdingWebOct 29, 2024 · CTGF and TGFβ were found to be increased in the alveolar epithelial cells inoculated with SARS-CoV-2 (Xu et al., 2024). As a … ipc holdq thresholdWebMar 18, 2010 · Connective tissue growth factor (CTGF) is a profibrogenic factor that stimulates fibroblast proliferation, cell adhesion, and extracellular matrix production (9,10). The potential role of CTGF in pathological fibrosis has been established , and CTGF has been suggested to be an attractive therapeutic target in some fibrotic diseases . ipc honduras 2018