Cthrc1 kda

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August undefined, 2024

Web30.5 kDa: Protein Length: Full Length of Mature Protein: Tag Info: ... CTHRC1 is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. PMID: 15618538; Aberrant expression of CTHRC1 is widely present in human solid ... WebCollagen triple helix repeat containing protein 1 (CTHRC1) is a 30 kDa secreted glycoprotein encoded by the CTHRC1 gene. CTHRC1 is known to regulate extracellular collagen deposition and partake in vascular remodeling of arterial injury as a function of cellular response through the TGF-β and Wnt pathways. Moreover,

Anti-CTHRC1 antibody (ab264410) Abcam

WebMay 22, 2024 · Collagen triple helix repeat containing 1 (CTHRC1), a secreted ECM protein, is a 28-kDa evolutionarily conserved extracellular matrix glycoprotein, containing an NH2-terminal signaling peptide for extracellular secretion, a short collagen triple helix repeat of 36 amino acids, and a COOH-terminal globular domain . how is radium dangerous

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WebCTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells. CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer. WebMay 19, 2014 · The gene that coded for collagen triple helix repeat containing 1 (CTHRC1), located at chromosome 8q22.3, was overexpressed in HCC compared with normal or liver cirrhosis tissues and identified as a new HCC-related gene. ... Fig. 1D shows that the 26-kDa CTHRC1 protein was expressed in membrane fractions of the HepG2 … WebCTHRC1, a 28-kDa secreted ECM protein, could promote cell migration via limiting collagen matrix deposition [16]. ... (TAMs) is associated with tumor progression and poor prognosis in endometrial ... how is radio waves used in everyday life

Review The Role of Collagen Triple Helix Repeat …

Recombinant Human CTHRC1 His Protein - Novus Biologicals

WebNational Center for Biotechnology Information WebCTHRC1 is a secreted 30 kDa glycoprotein that is highly conserved among vertebrates. The protein contains a N-terminal hydrophobic signal peptide that directs CTHRC1 for secretion, a short collagen triple helix repeat (CTHR) domain consisting of 12 repeats of the Gly-X-Y motif [11], and a how is radium found in natureWebAll lanes : Anti-CTHRC1 antibody (ab264410) at 1/1000 dilution Lane 1 : UACC-62 whole cell lysate Lane 2 : MALME-3M whole cell lysate Lane 3 : SR whole cell lysate Lane 4 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate Lysates/proteins at 50 µg per lane. Developed using the ECL technique. Predicted band … how is radio wave used

"WebCTHRC1 is a secreted glycoprotein with 12 repeats of the Gly-X-Y motif (a.a. 58-93 based on the pro-form seqeunce) that is reported to increase cell motility and promote cell migration by limiting the deposition of collagen matrix. " - Cthrc1 kda

Cthrc1 kda

CTHRC1 (human) (recombinant protein) - Order from Adipogen

WebOct 26, 2024 · The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. ... Highly conserved from lower chordates to mammals, the CTHRC1 protein was identified as a 30 kDa secreted protein and was first verified to be a differentially expressed gene in balloon-injured rat … WebApr 15, 2002 · Hepatocellular carcinoma (HCC) Malignant behaviors microRNA-155-5p (miR-155-5p) Collagen triple helix repeat containing 1 (CTHRC1) GSK-3β-involved Wnt/β-catenin signaling; ... Osteosarcoma microRNA-338-3p Activator of 90 kDa heat shock protein ATPase homolog 1 Tumor suppressor Translational repression; 82.

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WebThe molecular weight of secreted CTHRC1 (30 kDa) appears to be larger than that of cellular CTHRC1 (26 kDa). CTHRC1 has four different isoforms with molecular weights of about 12.3 kDa to 27 kDa ... WebMay 13, 2024 · CTHRC1 is highly expressed in patients with primary CRC and hepatic metastasis of CRC and predicts a poor prognosis. To …

WebThe recombinant human CTHRC1 consists of 224 amino acids and has a predicted molecular mass of 24.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CTHRC1 is approximately … WebOct 11, 2024 · Collagen triple helix repeat containing-1 (CTHRC1) is a 28-kDa secreted protein reported to be involved in vascular remodeling, bone formation and morphogenesis. This study aimed to investigate the role of CTHRC1 in promoting the metastasis of EOC and to elucidate the underlying molecular mechanisms.

WebCTHRC1 (Collagen triple helix repeat-containing protein 1) is a 28-30 kDa, secreted glycoprotein that bears similarity to the C1q/TNF alpha -related family of proteins. It is expressed by disparate cell types, including renal epithelium, neurons, osteoblasts, and smooth muscle cells. Web25.3 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. ... There are no reviews for CTHRC1 Recombinant Protein (NBP2-52008). By submitting a review you will ...

WebProteolytic processing may generate multiple CTHRC1 isoforms. There is the potential for an intracellular full-length 33 kDa, 245 aa form, plus extracellular isoforms that are 28 kDa (aa 33-245), 26 kDa (aa 49-245), 20 kDa (aa 98‑245) and 18 kDa and 16 kDa in size, the last two representing variants of the 20 kDa form with C-terminal processing.

WebFeb 9, 2012 · Collagen Triple Helix Repeat Containing-1 (CTHRC1) and Nuclear factor (erythroid-derived 2)-like 3 ... expression level in colorectal tumours when compared with normal tissues [9-12]. CTHRC1 is a 30 kDa secreted protein that has the ability to inhibit collagen matrix synthesis. how is radius related to diameterWebMar 1, 2005 · Collagen triple helix repeat containing 1 (CTHRC1) is a 28-kDa secreted glycoprotein containing a short collagen motif with 12 Gly-X-Y repeats, and it is highly conserved from lower chordates to ... how is radium isolatedWebMay 13, 2024 · CTHRC1 is highly expressed in patients with primary CRC and hepatic metastasis of CRC and predicts a poor prognosis. To identify the potential metastasis-associated genes in primary CRC, we first ... how is raf calculatedWebDec 23, 2004 · CTHRC1 is a secreted 28-kDa protein that is glycosylated and highly conserved from lower chordates to mammals. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the protein and this renders the molecule susceptible to cleavage by collagenase. how is radium madeWebOct 11, 2024 · Background Metastasis is the major cause of morbidity and mortality in patients with epithelial ovarian cancer (EOC), however the mechanisms that underline this process are poorly understood. Collagen triple helix repeat containing-1 (CTHRC1) is a 28-kDa secreted protein reported to be involved in vascular remodeling, bone formation … how is radium used in medicineWebCTHRC1 is specifically expressed in vascular calcifications of carotid artery lesions and may contribute to vascular remodeling of injured arteries (Pyagay et al., 2005 [PubMed 15618538]).[supplied by OMIM] how is radon testing doneWebCTHRC1 is overexpressed in multiple human cancers, and its expression is associated with increased migration and metastasis, as well as decreased survival (1-3). CTHRC1 expression is regulated through TGF-β/Smad3 … how is radium used in cancer treatment