WebJan 22, 2024 · @article{osti_22696806, title = {Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models}, author = {Liu, Wei and Gao, Yang and Chang, Na}, abstractNote = {The abnormality of nuclear receptor-related protein 1 (Nurr1) in … The human Nurr1 gene is located on chromosome 2q22-q23 and encodes a polypeptide of 598 amino acids that displays a high similarity (99%) with its bovine, porcine, and … See more Nur77 is located on the human chromosome 12q13.13. Human Nur77 cDNA encodes a polypeptide of 598 amino acids. The Nur77 … See more Nor1, which was first identified in nasopharyngeal carcinoma cells, has high similarity to the classical nitroreductase of Salmonella typhimurium [93]. Human Nor1 is also called human … See more
Dichotomous roles for the orphan nuclear receptor NURR1 in ..…
WebFurthermore, it has been reported that the defects in Nurr1 are associated with Parkinson's disease (PD). Thus, Nurr1 might be a potential therapeutic target for PD. Emerging evidence from in vitro and in vivo studies has recently demonstrated that Nurr1-activating compounds and Nurr1 gene therapy are able not only to enhance DA ... WebDec 4, 2024 · Evidence is provided that Nurr1 is expressed in a neuron‐specific manner in AD‐related brain regions; specifically, it is selectively expressed in glutamatergic neurons in the subiculum and the cortex of both normal and AD brains. The orphan nuclear receptor Nurr1 (also known as NR4A2) is critical for the development and maintenance of … darcy in distress by laraba kendig
Bidirectional and gene-selective Nurr1 modulation by NSAIDs?
WebAug 1, 2009 · Abstract. Nurr1 is a member of the NGFI-B nuclear orphan receptor family which includes two other members, Nur77 and Nor-1. Nurr1 is essential for the development and survival of dopaminergic neurons. It was reported that Nurr1 has antiapoptotic functions, however, the mechanisms by which Nurr1 mediates these effects remain … WebMar 21, 2013 · NURR1 is strongly expressed in normal, but not cancerous breast tissue. NURR1 impacts proliferation and differentiation in a context-dependent fashion. As such, … birthplace of the vile cheese