Dual specificity protein phosphatase 1

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August undefined, 2024

WebMar 21, 2024 · DUSP4 (Dual Specificity Phosphatase 4) is a Protein Coding gene. Diseases associated with DUSP4 include Ogden Syndrome.Among its related pathways are MyD88 dependent cascade initiated on endosome and RAF/MAP kinase cascade.Gene Ontology (GO) annotations related to this gene include phosphatase activity and … WebActs as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (PubMed:9187108, PubMed:9256433). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, …

Interaction of a Dual‐Specificity Protein Phosphatase with …

WebJun 25, 2024 · Our previous study demonstrated that dual-specificity protein phosphatase 1 (DUSP1) reduced hyperglycemia-mediated mitochondrial damage; however, its role in hyperglycemia-driven dysfunction of tubular cells is still not fully understood. In this study, we found that DUSP1 is reduced in human proximal tubular … WebJul 5, 2004 · PTHR47100:SF5 DUAL SPECIFICITY PROTEIN PHOSPHATASE PHS1 1 hit; PROSITE. View protein in PROSITE; PS00383 TYR_PHOSPHATASE_1 1 hit; PS50056 TYR_PHOSPHATASE_2 1 hit; PS50054 TYR_PHOSPHATASE_DUAL 1 hit; Pfam. View protein in Pfam; PF09192 Act-Frag_cataly 1 hit; PF00782 DSPc 1 hit; SMART. sypult construction

Dual function of protein phosphatase 5 (PPP5C): An emerging …

WebLokareddy et al. (2013) obtained the 1.68-angstrom crystal structure of a catalytically inactive mutant (cys152 to ser) of DUSP26 lacking the first 60 N-terminal amino acids. DUSP26 adopted a closed conformation of the protein tyrosine phosphatase (PTP)-binding loop, resulting in a shallow active-site pocket and buried catalytic cysteine. WebJan 7, 2014 · Dual specificity protein phosphatase 1 (DUSP1) is a key negative regulator of mitogen activated protein kinases (MAPKs). Yet, DUSP1 is overexpressed in pancreatic cancer cells (PCCs) in PDAC where it paradoxically enhances colony formation in soft agar and promotes in vivo tumorigenicity. However, it is not known whether DUSP1 … WebMar 7, 2006 · However, little is known on the functions of Ca 2+ /CaM-dependent protein kinases and phosphatases in Ca 2+ signaling in plants. From an Arabidopsis expression library, we isolated cDNA encoding a dual-specificity protein phosphatase 1 (DsPTP1), which is capable of hydrolyzing both phosphoserine/threonine and phosphotyrosine … sypte lighting

Dual-specificity phosphatase 6 (DUSP6): a review of its molecular ...

dual specificity protein phosphatase CDC14A isoform 2

WebOct 21, 2024 · Encodes a protein tyrosine phosphatase Propyzamide-Hypersensitive 1 (PHS1). One of the mutant alleles, phs1-1, is hypersensitive to the microtubule-destabilizing drug propyzamide, suggesting that PHS1 may be involved in phosphorylation cascades that control the dynamics of cortical microtubules in plant cells. A second allele, phs1-3, is … WebApr 7, 2024 · The primary structure of PPP5C can be mainly divided into three parts, the N-terminal tetrapeptide repeat (TPR) domain (residues 28–129), the middle phosphatase … sypublishWebJan 1, 2024 · Download Citation On Jan 1, 2024, Ruibing Li and others published Interaction between dual specificity phosphatase-1 and cullin-1 attenuates alcohol … syptosemic def

"WebMore>> The Dual Specificity Protein Phosphatase 1/6 Inhibitor, BCI controls the biological activity of Dual Specificity Protein Phosphatase 1/6. Primarily used for Phosphorylation & Dephosphorylation apps. Less<< MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. ... " - Dual specificity protein phosphatase 1

Dual specificity protein phosphatase 1

Frontiers Role of Dual-Specificity Phosphatase 1 in …

WebSep 27, 2024 · LSF2 is a dual specificity protein phosphatase that displays high activity toward para-nitrophenyl phosphate ... Dietrich H, Servatius A, Howells N, Cato AC, Lang R (2006) Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med 203(1):15–20. WebDual specificity phosphatases (DSPs) are an emerging subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which appears to be selective for dephosphorylating the critical phosphothreonine and phosphotyrosine residues within MAP kinases. Some DSPs are localized to different subcellular compartments and moreover, certain family ...

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WebApr 10, 2024 · dual specificity protein phosphatase CDC14A isoform 2 Download Models. Job ID Status Method Username Target Length Date (PST) Expiration Date … WebMar 29, 2024 · HVH1; MKP1; CL100; MKP-1; PTPN10. Summary. The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The …

WebMar 1, 2002 · Dual specificity phosphatase TS-DSP1; Low molecular weight dual specificity phosphatase 3 (LMW-DSP3) ... PTHR46377 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 1 hit; PTHR46377:SF1 DUAL SPECIFICITY PROTEIN PHOSPHATASE 19 1 hit; PRINTS. PR01908 ADSPHPHTASE; PROSITE. View protein … The human genome encodes at least 61 different DUSP proteins. The following major groups or families of DUSPs were identified: • Slingshot phosphatases: There are three members of this family (SSH1L, SSH2L and SSH3L) with broad specificity. They contain SH3-binding motifs as well as F-actin binding motifs, thus they are generally believed t…

WebProtein tyrosine phosphatase non-receptor 12 (PTPN12) is an important protein tyrosine phosphatase involved in regulating cell adhesion and migration as well as tumorigenesis. Here, we solved a crystal structure of the native PTPN12 catalytic domain with the catalytic cysteine (residue 231) in dual conformation (phosphorylated and unphosphorylated). … WebPTPN13 is a soluble and cytosolic non-receptor protein that can be translocated to the sub-membranous and nuclear compartments [ 7] during mitosis [ 8 ]. The PTPN13 gene is located on chromosome 4q21.3 and encodes the non-receptor protein phosphatase with the highest molecular weight (270 kDa; 2466 amino acids) [ 9 ].

Web24 rows · Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and ... syptons of a bad thermostat on a honda fitWebApr 10, 2024 · dual specificity protein phosphatase CDC14A isoform 2 Download Models. Job ID Status Method Username Target Length Date (PST) Expiration Date (PST) 505201: Complete: Structure prediction : sabdus: dual specificity protein ... 623: 10 Apr 2024: 25 May 2024: 1 . 10 . 20 . 30 . 40 . 50 . 60 . 70 . 80 . 90 . 100 . ... syr 3 invito al ĉieloWebMay 31, 1996 · Dual specificity protein phosphatases (DSPs) regulate mitogenic signal transduction and control the cell cycle. Here, the crystal structure of a human DSP, … syptoms cough onlyWebPTHR45961:SF5 DUAL SPECIFICITY PROTEIN PHOSPHATASE 14 1 hit; PTHR45961 IP21249P 1 hit; PRINTS. PR01908 ADSPHPHTASE; PR01910 ADSPHPHTASEB; PROSITE. View protein in PROSITE; PS00383 TYR_PHOSPHATASE_1 1 hit; PS50056 TYR_PHOSPHATASE_2 1 hit; PS50054 TYR_PHOSPHATASE_DUAL 1 hit; Pfam. … syr .com obitsWebGlucocorticoids (GCs) potently inhibit pro-inflammatory responses and are widely used for the treatment of inflammatory diseases, such as allergies, autoimmune disorders, and asthma. Dual-specificity phosphatase 1 … syr alin the lion\u0027s clawWebThe structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC 50 value of 3.0 ± 0.2 μM. sypthomWebDec 8, 2024 · Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. … syr acronym