Hif bnip3
WebOverexpression of BNIP3 in Rat-1 fibroblasts and breast cancer cells (MCF7) induces apoptosis by binding to and inhibiting the antiapoptotic proteins Bcl-2 and Bcl-xL. 57 Hypoxia induced apoptosis mediated by … Web2 de set. de 2024 · 3.3. HIF-1α/BNIP3 Pathway Was Activated during Luteolysis. Previous studies have revealed that hypoxia is involved in the apoptosis of luteal cells in vitro [], implying that HIF-1α may participate in apoptosis during luteal regression in vivo.Thus, we detected the expression changes of HIF-1α signaling and then found an obvious …
Hif bnip3
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Web1 de set. de 2001 · To additionally check the role of Hif-1α in BNIP3 induction, CHO KA13 and C4.5 cells were subjected to normoxia or hypoxia for 16 h before being analyzed … Web6 de abr. de 2024 · HIF-1-dependent BNIP3 expression was proven to induce mitophagy in prolonged hypoxia . HIF-1 enhances the expression of BNIP3 and its closely related protein BNIP3L by directly binding to HREs on ...
Web5 de jan. de 2024 · We identified that the Bcl-2/adenovirus E1B 19-kDa interacting protein (bnip3) functions as a regulator of mitophagy in M. nipponense and demonstrated that hif-1α activates bnip3 by binding to the bnip3 promoter. Hif-1α knockdown suppressed the expression of multiple mitophagy-related genes, and prawns with hif-1α knockdown … WebBNIP3 is an atypical BH3-only protein that is known to cause mitochondrial dysfunction and cell death, but in parallel has also a role in protecting against cell death by inducing mitophagy. The mechanism for this process, however, remains poorly understood.
Web4 de abr. de 2011 · The data also showed that the activation of autophagy under hypoxic conditions was caused by up-regulated expression of hypoxia-inducible factor-1α (HIF … Web7 de ago. de 2024 · HIF-1α-BNIP3 signaling pathway contributes to mitophagosome formation in renal tubular cells in confocal assay. Representative immunofluorescence images (A) and summarized data (C) showing the inhibitory effect of HIF-1α siRNA on H/R-induced mitophagosome formation as indicated by the colocalization of LC3B with …
Web18 de mar. de 2024 · HIF-1a was stabilised by 4 and 6 h OGD in PC12 cells and 2 h OGD onwards in primary neurons. A panel of hypoxic genes were upregulated by the OGD treatments depending on the duration. ... Bnip3 levels in PC12 cells were not changed during the shorter period of OGD (from 2 to 12 h), ...
WebHIF-1 and HIF-2 appear to be evenly matched in their capacity to induce BNIP3-dependent autophagy. In agreement with these studies, HIF-1-dependent expression of BNIP3 was described to be essential in mitochondrial autophagy (also called mitophagy), as described in MEFs (Zhang et al., 2008) and later in mole rat heart tissue (Band et al., 2009). cincinnati and hamilton libraryWeb目前认为低氧是通过hif-1诱导的非典型性唯bh3域蛋白 bcl-2/e1b 19 kda交互蛋白 3[bnip3/bnip3l(nix)]和mtor而介导细胞发生自吞噬作用的。 这些线粒体相关BNIP蛋白能介导线粒体自吞噬(mitophagy),而线粒体自吞噬反应能控制活性氧族(reactive oxygen species,ROS)的产生和DNA受损的代谢,从而使细胞产生适应性存活 ... cincinnati auto credit beechmont aveWeb1 de dez. de 2024 · By contrast, the excitomotor of HIF-1α significantly increased BNIP3 expression under OGD/R injury, which was correlated with HIF-1α expression. … cincinnati bengals tv schedule 2021Web21 de mar. de 2024 · BNIP3 (BCL2 Interacting Protein 3) is a Protein Coding gene. Diseases associated with BNIP3 include Hereditary Leiomyomatosis And Renal Cell … cincinnati bengals missed field goalWebAlternatively, a variety of mitophagy receptors, including BNIP3L, BNIP3, FUNDC1 ... Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell … cincinnati financial homeowners insuranceWeb27 de dez. de 2024 · HIF-1 α exerts its antiapoptotic function through transcriptional activation of antiapoptotic proteins: Bcl-2, apoptosis inhibitor (IAP-2), and GLUT1. On the other hand, a functional pathway of HIF-1 α can activate proapoptotic proteins: p53, Bax, and BNIP3 [ 5 ]. cincinnati red stockings name originWeb27 de jul. de 2024 · (Bnip3) was substantially upregulated in the inner retinal layer after retinal I/R. In this regard, we further examined Bnip3 depletion in retinal neurons in vitro … cincinnati bengals kicker