Phospholipase a2 receptor antibody pla2r
WebJun 29, 2016 · The phospholipase A2 receptor (PLA2R) is the major target antigen (Ag) in idiopathic membranous nephropathy (IMN). Recently, several types of immunoassay … Webbeck等 首次在成人imn患者血清中检测到抗m型磷脂酶a2受体(pla2r)的自身抗体,并发现抗体滴度与患者蛋白尿的消长相关,提示pla2r可能是imn的重要靶抗原。我们前期已针对血清pla2r抗体进行检测,发现病情缓解的imn患者血清学阳性率明显降低,提示单纯采用血 …
Phospholipase a2 receptor antibody pla2r
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WebPhospholipases A 2 include several unrelated protein families with common enzymatic activity. Two most notable families are secreted and cytosolic phospholipases A 2. Other families include Ca 2+ independent PLA2 (iPLA2) and lipoprotein-associated PLA2s (lp-PLA2), also known as platelet activating factor acetylhydrolase (PAF-AH). WebJun 29, 2016 · The phospholipase A2 receptor (PLA2R) is the major target antigen (Ag) in idiopathic membranous nephropathy (IMN). Recently, several types of immunoassay …
WebMar 21, 2024 · PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging. Phospholipase A2 receptor 1 promotes lung cell senescence and … WebApr 11, 2024 · Approximately 80% of PMN cases arise due to autoantibodies that recognize the phospholipase A2 receptor (PLA2R) antigen expressed on podocytes. Anti-PLA2R is both a diagnostic and prognostic biomarker, and total aPLA2R antibody level has been shown to be a biomarker for prognosis of outcome in patients with PMN.
WebApr 15, 2024 · Both blood phospholipase A2 receptor -Ab and kidney tissue phospholipase A2 receptor were negative. Thirty-six patients received glucocorticosteroids and/or immunosuppressants. ... (ANA), ds-DNA, complement C3 and C4, and antiphospholipase A2 receptor (PLA2R) antibodies. Pathological data. All patients underwent a renal biopsy. … WebJan 3, 2024 · Phospholipase A2 receptor (PLA2R) is the most common primary target antigen of idiopathic membranous nephropathy (MN) although PLA2R antibodies are also reported to be present in malignancy-associated MN. However, a case of PLA2R-positive MN secondary to PLA2R-positive carcinoma has not been reported.
WebObjective To explore the value of anti-phospholipase A2 receptor (PLA2R) antibody in the diagnosis and disease activity monitoring of idiopathic membranous nephropathy …
WebFeb 20, 2024 · M-type phospholipase A2 receptor 1 (PLA2R) has been described as a major antigen in iMN, with anti-PLA2R antibodies (Abs) present in ∼70% of incident patients [ 2, 3 ]. The specificity of anti-PLA2R Abs for the diagnosis of iMN, albeit not absolute, is now well established [ 3–5 ]. sims 3 ea app expansion packs not installingWebAnti-PLA2R antibody [CL0474] (ab188028) Datasheet SDS Submit a review Submit a question References (2) Key features and details Mouse monoclonal [CL0474] to PLA2R Suitable for: IHC-P, WB, ICC Reacts with: Human Isotype: IgG1 You may also be interested in Primary Anti-Ext1 antibody (ab126305) Peptide PLA2R peptide (ab176432) rbc bow trail branch calgaryWebAnti-phospholipase A2 receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy. If a patient is already known to have anti … rbc bourseWebApr 15, 2024 · Both blood phospholipase A2 receptor -Ab and kidney tissue phospholipase A2 receptor were negative. Thirty-six patients received glucocorticosteroids and/or … sims 3 download for pcWebSep 18, 2024 · Currently, serum M-type phospholipase A2 receptor antibody (sPLA2R-ab) is emerging as a predictive biomarker for early prognosis of PMN. In 2009, Beck et al. [ 2 ] … sims 3 ds coverWebRecent studies have shown that in approximately 70% of patients with primary MN (pMN), the immune complexes consist of autoantibodies against the podocyte protein M-type phospholipase A2 receptor (PLA2R).(1) There is also evidence that levels of anti-PLA2R autoantibodies correlate well with disease activity and progression.(2) The presence of ... rbc bow trail calgaryWebMar 14, 2024 · The discovery of antibodies against M-type phospholipase A2 receptor (PLA2R) situated on the cell surface of human podocytes has been a turning point for the … sims 3 earrings