WebAug 13, 2024 · Here we report that large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, is activated under diabetic conditions and induces β-cell … WebJul 4, 2024 · The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis. ... (lower panel) of INS-1E cells transfected with GFP or kinase-dead form of LATS2 (LATS2 ...
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WebNov 4, 2008 · The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WebDec 1, 2016 · The heart of the mammalian Hippo pathway is a kinase cascade involving mammalian STE20-like protein kinase 1 (MST1; also known as STK4) and MST2 (also known as STK3) (homologs of Drosophila Hippo), as well as two groups of MAP4Ks (mitogen-activated protein kinase kinase kinase kinases)—MAP4K1/2/3/5 (homologs of Drosophila … look up an npn number
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WebDec 1, 2024 · To explore the regulatory mechanism of LATS2 through mediating the Hippo/MST signaling cascades in ovarian follicular growth and development, effects of … WebApr 13, 2024 · HIGHLIGHTS SUMMARY As research on the Hippo signaling path has gradually deepened, the authors have found that it not only regulates the size of organs but also its dysregulation is … Identifying lats2 as a prognostic biomarker relevant to immune ltrates in human esophageal squamous cell carcinoma Read Research » WebMar 14, 2013 · Mammalian Ste20-like kinases 1 and 2 (MST1 and MST2) are activated in NIH3T3 cells exposed to okadaic acid. The Hippo pathway is a newly emerging signaling that functions as a tumor suppressor. MST1 and MST2 work as core kinases of the Hippo pathway and their activities depend on the autophosphorylation, which is negatively … look up an llc in ohio