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Lynch Syndrome Cancer.Net
Web18 Nov 2015 · UMD-MSH2. mutations database. Home. The UMD-MMR databases have been set up in a joined national effort through the network of 16 diagnostic laboratories to … UMD-MSH2. mutations database. Mutations involving exon 1. Request ID: … WebMSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3 to form the MutSβ DNA repair complex. how cool dishwasher hot water
UMD-MLH1/MSH2/MSH6 databases: description and analysis of …
WebThe UMD-MSH2 mutations database Mutation p.Glu878Asp (c.2634G>C) Wild type amino acid: Glu: Mutant amino acid: Asp: ... Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation) Sample ID MSH2 MLH1 MSH6 MUTYH APC; WebThe highest homology is to the yeast Msh2 gene in the helix-turn-helix domain, perhaps responsible for MutS binding to DNA. The yeast and human Msh2 proteins are 77% identical between codons 615 and 788. There are 10 other blocks of similar amino acids distributed throughout the length of the 2 proteins. WebUMD-predictor (0-100) mmruv database; 1: 0.00 (pathogenous) 94 (Pathogenous) not reported: Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic … how cool can aircondition go